Yield is the percentage of chips that are functional. Roughly, you can think of it as the probability of a chip having 0 defects. The bigger the chip, or the higher the defect density, the lower this probability becomes. Chip designers will also include mitigation techniques (e.g. redundancy) to allow chips to work even with some defects.
This seems to be a limitation of Intel host controllers. The USB 2.0 specification (including 12 Mbps Full Speed) allows for up to 127 devices. Each of those devices can have up to 16 IN and 16 OUT endpoints, c.f. https://www.usbmadesimple.co.uk/ums_3.htm Depending on how you count, that would be a maximum of 2k to 4k endpoints in total. I guess Intel thought it wasn’t worthwhile supporting that many endpoints.
Some quick searching turned up this post that claims that USB3 controllers often support up to 254 endpoints (in total). https://www.cambrionix.com/a-quick-guide-to-usb-endpoint-limitations/ Other posters have also said that AMD appears to have higher limits. You could also consider adding more USB root hubs to your system (with PCIe cards).